Crutcher, K. A. (1990). The regulation of axonal growth in the mature mammalian nervous system. [Review]. Acta Neurobiologiae Experimentalis, 50(4-5):115-24.
Abstract
Studies of a specific neuronal rearrangement that occurs in the
mature rat nervous system have led to conclusions regarding the
regulation of axonal growth in maturity and aging. In this brief
review, the results of recent experiments are summarized and the
general conclusions presented. One hypothesis that has emerged from
these studies is that the extent of growth of one portion of a
neuron's axonal arbor may affect the potential for growth at another
portion of the arbor. In addition, evidence has been obtained in
favor of the hypothesis that the decline in neuronal plasticity that
occurs in aging is primarily due to a decrease in the support of
axonal growth by the CNS environment. Finally, evidence is reviewed
for the presence of growth-inhibiting activity of CNS white matter.
Each of these findings has potential implications for understanding
the regulation of axonal growth in the mature and aging brain.
[References: 32]
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