Kesner, R. P., Crutcher, K. A., Omana, H. (1990). Memory deficits following nucleus basalis magnocellularis lesions may be mediated through limbic, but not neocortical, targets. Neuroscience, 38(1):93-102.
Abstract
In order to test the contribution of the target areas of the nucleus
basalis magnocellularis to the mediation of item and order
recognition memory for spatial locations, one set of rats received
lesions of the dorsolateral frontal cortex, parietal cortex, or
basolateral amygdala after training in an order recognition memory
task, whereas another set of animals received lesions of the nucleus
basalis magnocellularis or basolateral amygdala in an item
recognition memory task. Animals with basolateral amygdala lesions
displayed a deficit for order recognition memory, but no deficit for
item recognition memory, a pattern equivalent to that found for
animals with nucleus basalis magnocellularis lesions. In contrast,
animals with dorsolateral frontal cortex displayed no deficit, and
animals with parietal cortex lesions displayed only a partial
deficit for order recognition memory, results that differ from those
found for animals with nucleus basalis magnocellularis lesions. It
appears that the nucleus basalis magnocellularis influences item and
order recognition memory for lists of spatial locations primarily
through projections to limbic but not neocortical targets.
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