Crutcher, K. A., and Privitera, M. (1989). Axonal regeneration on mature human brain tissue sections in culture. Annals of Neurology, 26(4):580-3.
Abstract
Fresh frozen sections of the temporal lobe from patients undergoing
surgical resection for the control of epilepsy were used as a
substrate in tissue culture to test for neurite growth-promoting
activity. Robust neurite growth from ganglia of embryonic chicks was
observed on gray matter regions of the sections and little growth
was observed on white matter regions. These results indicate that
the dichotomy between gray and white matter regions of the mature
central nervous system in supporting neurite growth is present in
human brain tissue and supports the general hypothesis that white
matter in the mature central nervous system inhibits neurite
regeneration but that gray matter will support neurite growth.
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