Collins, F. and Crutcher, K. A. (1989). Sustained elevation in hippocampal NGF-like biological activity following medial septal lesions in the rat. Brain Research, 490(2):355-60.

Abstract

Several laboratories have documented an increase in hippocampal nerve growth factor (NGF) levels, measured with biological or immunological assays, within 1-2 weeks following septal lesions or fimbria/fornix transections. In the present study we have determined the increase in NGF-like biological activity in medium conditioned by hippocampal slices at more prolonged times following medial septal lesion. In contrast to reports based on immunological assays, which demonstrate a transient increase in hippocampal NGF, elevated NGF-like biological activity was present in hippocampal slice-conditioned medium up to one year after a medial septal lesion.

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