Crutcher, K. A. ,Danscher, G., Geneser, F. A. (1988). Hippocampus and dentate area of the European hedgehog. Comparative histochemical study. Brain, Behavior & Evolution, 32(5):269-76.
Abstract
The hippocampal formation in the European hedgehog was examined with
acetylcholinesterase (AChE) histochemistry and catecholamine
histofluorescence in order to define the normal distribution of
septohippocampal fibers and noradrenergic fibers, respectively, as
well as to compare these inputs with the hippocampal
cytoarchitecture as revealed with Nissl stain. In addition,
alterations in the histochemical appearance following
septohippocampal denervation were examined. Although the overall
pattern of AChE-positive and noradrenergic fibers is similar to that
observed in other mammals, some striking variations were observed,
particularly within the dentate area. Thus, except for a heavily
stained supragranular band, the AChE activity of the molecular layer
is uniformly low without any obvious lamination, contrasting with
the situation in most other mammalian species. The noradrenergic
innervation of the dentate area showed the same density of fibers in
the molecular layer and hilus, a pattern differing strikingly from
the predominance of noradrenergic fibers in the hilus of other
mammalian species. Such variations may reflect greater phylogenetic
diversity in diffuse modulatory connections as compared with more
precise topographical pathways.
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