Cook, T. M., Crutcher, K. A. (1988). Lesion-induced CA1 mossy fibers in the rat represent a neoinnervation. Experimental Brain Research, 70(2):433-6.
Abstract
The developmental pattern of hippocampal mossy fiber (dentate
granule cell axon) innervation to the pyramidal cell layer was
examined with anterograde transport methods. Injection of 3H-leucine
into the dentate gyrus on PN 1 resulted in labeling of the incipient
stratum lucidum extending to, but not beyond, the CA3 region on PN 3
and 5. Since destruction of CA3 pyramidal cells on PN 5 results in
aberrant mossy fiber innervation to CA1 pyramidal cells (Cook and
Crutcher 1985), these results suggest that the presence of mossy
fibers in CA1 of the rat represents a neoinnervation (perhaps
representing a more primitive pattern of connectivity) and not the
persistence of a transient developmental projection.
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