Kesner, R. P., Adelstein, T., and Crutcher, K. A. (1987).
Rats with nucleus basalis magnocellularis lesions mimic mnemonic
symptomatology observed in patients with dementia of the Alzheimer's type. Behavioral Neuroscience, 101(4):451-6.
Abstract
College students, healthy elderly subjects, patients diagnosed with
mild or moderate dementia of the Alzheimer's type, as well as rats
with small or large lesions of nucleus basalis magnocellularis (NBM)
were tested on an order memory task for a 6- or 8-item list of
varying spatial locations. Similar patterns of order memory deficits
as a function of serial order position were observed in rats with
small or large NBM lesions and patients with mild or moderate
dementia of the Alzheimer's type. The results provide support for
the possibility that rats with NBM lesions might mimic the mnemonic
symptomatology of Alzheimer's disease.
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