Chronological Listing of Publications
2001
S. Joshi and K.A. Crutcher, Rat microglia exhibit increased density
on Alzheimer’s plaques in vitro, Exp. Neurol., 149:42-50 (1998). Abstract
M. Tolar, S.A. Scott and K.A. Crutcher, Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections, Brain Research, 787:49-58 (1998). Abstract
L.G. Isaacson and K.A. Crutcher, Uninjured aged sympathetic neurons sprout in response to exogenous NGF in vivo, Neurobiology of Aging, 19:333-339 (1998). Abstract
1997
K.A. Crutcher, M. Tolar, J.A.K. Harmony and M.A. Marques, A new
hypothesis for the role of apolipoprotein E in Alzheimer’s disease
pathology, Alzheimer’s Disease: Biology, Diagnosis and Therapeutics,
Eds. K. Iqbal, B. Winblad, T. Nishimura, M. Takeda and H.M. Wisniewski,
John Wiley & Sons, 1997, pp. 543-552. Abstract
M.A. Marques, M. Tolar and K.A. Crutcher, Apolipoprotein E exhibits
isoform-specific neurotoxicity, Alzheimer’s Research, 3:1-6 (1997). Abstract
M. Tolar, M.A. Marques, J.A.K. Harmony and K.A. Crutcher,
Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein
E and related synthetic peptides is receptor-mediated, J. Neurosci.,
17:5678-5686 (1997). Abstract
M.D. Kawaja and K.A. Crutcher, Sympathetic axons invade the brains
of mice overexpressing nerve growth factor, J. Comp. Neurol., 383:60-72
(1997). Abstract
1996
Tian, X., Scott, S. A., Weingartner, J.A., and Crutcher, K.A. Enhanced sympathetic neurite outgrowth on rat hippocampal tissue sections following septal lesions, Brain Research, 725:111-114 (1996). Abstract
M.A.Marques, M. Tolar, J.A.K. Harmony and K.A. Crutcher, A
thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific
neurotoxicity, NeuroReport, 7:2529-2532 (1996). Abstract
T. Cowen, I. Gavazzi, J. Weingartner and K.A. Crutcher, Levels of NGF protein do not correlate with changes in innervation of the rat iris in old age, NeuroReport, 7:2216-2220 (1996). Abstract
M. Fahnestock, S.A. Scott, N. Jette, J.A. Weingartner and K.A. Crutcher, Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex, Molecular Brain Research, 42:175-178 (1996). Abstract
1995
Scott, S.A, Mufson, E.J., Weingartner, J.A., Skau, K.A. and Crutcher, K.A. (1995). Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. Journal of Neuroscience15,(9), 6213-21.
Abstract
Yu, C. and Crutcher, K.A. (1995).
Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation. Brain Research, 672, (1-2):55-67. Abstract
Isaacson, L. G. and Crutcher, K. A. (1995).
The duration of sprouted cerebrovascular axons following
intracranial infusion of nerve growth factor. Experimental Neurology,131, (2):174-9. Abstract
1994
Crutcher, K. A., Clay, M. A., Scott, S. A., Tian, X., Tolar, M., Harmony, J. A. (1994). Neurite degeneration elicited by apolipoprotein E peptides. Experimental Neurology,130, (1):120-6. Abstract
Scott, S. A., Liang, S., Weingartner, J. A., and Crutcher, K. A. (1994).
Increased NGF-like activity in young but not aged rat hippocampus
after septal lesions. Neurobiology of Aging,15(3):337-46. Abstract
Scott, S. A., and Crutcher, K. A. (1994). Nerve growth factor and Alzheimer's disease. [Review] Reviews in the Neurosciences,5, (3):179-211. Abstract
1993
Carpenter, M. K., Crutcher, K. A., and Kater, S. B. (1993).
An analysis of the effects of Alzheimer's plaques on living neurons.
Neurobiology of Aging,14, (3):207-15. Abstract
Crutcher, K. A., Scott, S. A., Liang, S., Everson, W. V., and Weingartner J. (1993). Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease.
Journal of Neuroscience,13, (6):2540-50. Abstract
Liang, S., and Crutcher, K. A. (1993). Movement of embryonic chick sympathetic neurons on laminin in vitro is preceded by neurite extension. Journal of Neuroscience Research, 36, (6):607-20. Abstract
Crutcher, K. A., Anderson, B. H., Barger, S. W., Ohm, T. G., and Snow, A. D. (1993). Cellular and molecular pathology in Alzheimer's disease. [Review] Hippocampus,3 Spec No:271-87.
Crutcher, K. A. (1993). Tissue sections as culture substrates: overview and critique. [Review] Hippocampus, 3 Spec No:157-63.
1992
Liang, S., and Crutcher, K. A. (1992). Neuronal migration on laminin in vitro. Brain Research. Developmental Brain Research, 66, (1):127-32. Abstract
Isaacson, L. G., Saffran, B. N., and Crutcher, K. A. (1992). Nerve growth factor-induced sprouting of mature, uninjured sympathetic axons. Journal of Comparative Neurology, 326, (3):327-36. Abstract
1991
Crutcher, K. A. (1991). How to succeed in science. Perspectives in Biology & Medicine,34(2):213-8 Abstract
Crutcher, K. A. and Weingartner, J. (1991). Hippocampal NGF levels are not reduced in the aged Fischer 344 rat. Neurobiology of Aging,12(5):449-54 Abstract
Crutcher, K. A., Neaderhauser, J., Schmidt, P., and Weingartner, J. (1991). Neurite outgrowth on postmortem human brain cryostat sections: studies of non-Alzheimer's and Alzheimer's tissue.
Experimental Neurology, 114(2):228-36. Abstract
1990
Crutcher, K. A. (1990). Age-related decrease in sympathetic sprouting is primarily due to decreased target receptivity: implications for understanding brain aging. Neurobiology of Aging, 11(3):175-83. Abstract
Isaacson, L. G., Saffran, B. N., and Crutcher, K. A. (1990). Intracerebral NGF infusion induces hyperinnervation of cerebral
blood vessels. Neurobiology of Aging, 11(1):51-5. Abstract
Crutcher, K. A. (1990). Research on human embryos [letter] [see comments]. Nature, 343(6253):10.
Saffran, B. N., and Crutcher, K. A. (1990). NGF-induced remodeling of mature uninjured axon collaterals. Brain Research, 525(1):11-20. Abstract
Crutcher, K. A. (1990). The regulation of axonal growth in the mature mammalian nervous system. [Review]. Acta Neurobiologiae Experimentalis, 50(4-5):115-24. Abstract
Kesner, R. P., Crutcher, K. A., Omana, H. (1990). Memory deficits following nucleus basalis magnocellularis lesions may be mediated through limbic, but not neocortical, targets. Neuroscience, 38(1):93-102. Abstract
1989
Crutcher, K. A., and Privitera, M. (1989). Axonal regeneration on mature human brain tissue sections in culture. Annals of Neurology, 26(4):580-3. Abstract
Kesner, R. P., Adelstein, T. B., and Crutcher, K. A. (1989). Equivalent spatial location memory deficits in rats with medial
septum or hippocampal formation lesions and patients with dementia of the Alzheimer's type. Brain & Cognition, 9(2):289-300. Abstract
Collins, F. and Crutcher, K. A. (1989). Sustained elevation in hippocampal NGF-like biological activity following medial septal lesions in the rat. Brain Research, 490(2):355-60. Abstract
Saffran, B. N., Woo, J. E., Mobley, W. C., and Crutcher, K. A. (1989). Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth. Brain Research, 492(1-2):245-54. Abstract
Crutcher, K. A. (1989). Tissue sections from the mature rat brain and spinal cord as substrates for neurite outgrowth in vitro: extensive growth on gray matter but little growth on white matter.
Experimental Neurology,104(1):39-54. Abstract
1988
Crutcher, K. A. and Marfurt, C. F. (1988). Nonregenerative axonal growth within the mature mammalian brain: ultrastructural identification of sympathohippocampal sprouts. Journal of Neuroscience, 8(7):2289-302. Abstract
Crutcher, K. A. (1988). Fetal research ban [letter]. Science, 242(4883):1227.
Crutcher, K. A., Danscher, G., Geneser, F. A. (1988). Hippocampus and dentate area of the European hedgehog. Comparative histochemical study. Brain, Behavior & Evolution, 32(5):269-76. Abstract
Cook, T. M., Crutcher, K. A. (1988). Lesion-induced CA1 mossy fibers in the rat represent a neoinnervation. Experimental Brain Research, 70(2):433-6. Abstract
1987
Saffran, B. N., and Crutcher, K. A. (1987). Putative gliotoxin, alpha-aminoadipic acid, fails to kill hippocampal astrocytes in vivo.
Neuroscience Letters, 81(1-2):215-20. Abstract
Crutcher, K. A. (1987). Sympathetic sprouting in the central nervous system: a model for studies of axonal growth in the mature mammalian brain [published erratum appears in Brain Res 1987 Nov;434(4):467]. [Review] Brain Research, 434(2):203-33. Abstract
Kesner, R. P., DiMattia, B. V., and Crutcher, K. A. (1987). Evidence for neocortical involvement in reference memory.
Behavioral & Neural Biology, 47(1):40-53. Abstract
Kesner, R. P., Adelstein, T., and Crutcher, K. A. (1987).
Rats with nucleus basalis magnocellularis lesions mimic mnemonic
symptomatology observed in patients with dementia of the Alzheimer's type. Behavioral Neuroscience, 101(4):451-6. Abstract
1986
Cook, T. M., and Crutcher, K. A. (1986). Intrahippocampal injection of kainic acid produces significant pyramidal cell loss in neonatal rats. Neuroscience,18(1):79-92. Abstract
Kesner, R. P., Crutcher, K. A., Measom, M. O. (1986). Medial septal and nucleus basalis magnocellularis lesions produce order memory deficits in rats which mimic symptomatology of Alzheimer's disease. Neurobiology of Aging, 7(4):287-95. Abstract
Crutcher, K. A. and Collins, F. (1986). Entorhinal lesions result in increased nerve growth factor-like growth-promoting activity in medium conditioned by hippocampal slices. Brain Research, 399(2):383-9. Abstract
Crutcher, K. A. (1986). The role of growth factors in neuronal development and plasticity. [Review] CRC Critical Reviews in Clinical Neurobiology, 2(3):297-333. Abstract