Topics

1) Axonal sprouting following CNS injury ,
2) White matter inhibition of axonal regeneration,
3) NGF-induced axonal sprouting ,
4) Neuronal plasticity in aging,
5) NGF in Alzheimers Disease,
6) Plaques and ApoE in Alzheimers Disease,
O) Other Publications

1) Axonal sprouting following CNS injury

Tian, X., Scott, S. A., Weingartner, J.A., and Crutcher, K.A. Enhanced sympathetic neurite outgrowth on rat hippocampal tissue sections following septal lesions, Brain Research, 725:111-114 (1996). Abstract

Yu, C. and Crutcher, K.A. (1995). Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation. Brain Research, 672, (1-2):55-67 Abstract

Crutcher, K. A. (1990). The regulation of axonal growth in the mature mammalian nervous system. [Review]. Acta Neurobiologiae Experimentalis, 50(4-5):115-24. Abstract

Collins, F. and Crutcher, K. A. (1989). Sustained elevation in hippocampal NGF-like biological activity following medial septal lesions in the rat. Brain Research, 490(2):355-60. Abstract

Crutcher, K. A. and Marfurt, C. F. (1988). Nonregenerative axonal growth within the mature mammalian brain: ultrastructural identification of sympathohippocampal sprouts. Journal of Neuroscience, 8(7):2289-302. Abstract

Cook, T. M., Crutcher, K. A. (1988). Lesion-induced CA1 mossy fibers in the rat represent a neoinnervation. Experimental Brain Research, 70(2):433-6. Abstract

Crutcher, K. A. (1987). Sympathetic sprouting in the central nervous system: a model for studies of axonal growth in the mature mammalian brain [published erratum appears in Brain Res 1987 Nov;434(4):467]. [Review] Brain Research, 434(2):203-33. Abstract

Crutcher, K. A. (1986). The role of growth factors in neuronal development and plasticity. [Review] CRC Critical Reviews in Clinical Neurobiology, 2(3):297-333. Abstract

2) White matter inhibition of axonal regeneration

D.B. Pettigrew and K. A. Crutcher, Myelin contributes to the parallel orientation of axonal growth on white matter in vitro BMC Neuroscience, 2:9 (2001). Abstract

D.B. Pettigrew, K. P. Shockley and K. A. Crutcher, Disruption of spinal cord white matter and sciatic nerve geometry inhibits axonal growth in vitro in the absence of glial scarring, BMC Neuroscience, 2:8 (2001). Abstract

D.B. Pettigrew and K.A. Crutcher, White matter of the CNS supports or inhibits neurite outgrowth in vitro depending on geometry, J. Neurosci., 19(19):8358-66 (1999). Abstract Full Text

Crutcher, K. A., and Privitera, M. (1989). Axonal regeneration on mature human brain tissue sections in culture. Annals of Neurology, 26(4):580-3. Abstract

Crutcher, K. A. (1989). Tissue sections from the mature rat brain and spinal cord as substrates for neurite outgrowth in vitro: extensive growth on gray matter but little growth on white matter. Experimental Neurology,104(1):39-54. Abstract

3) NGF-induced axonal sprouting

G.S. Walsh, K.M. Krol, K.A. Crutcher and M.D. Kawaja, Enhanced neurotrophin-induced axon growth in myelinated portions of the CNS in mice lacking the p75 neurotrophin receptor, J. Neurosci., 19:4155-4168 (1999). Abstract

L.G. Isaacson and K.A. Crutcher, Uninjured aged sympathetic neurons sprout in response to exogenous NGF in vivo, Neurobiology of Aging, 19:333-339 (1998). Abstract

M.D. Kawaja and K.A. Crutcher, Sympathetic axons invade the brains of mice overexpressing nerve growth factor, J. Comp. Neurol., 383:60-72 (1997).Abstract

Isaacson, L. G. and Crutcher, K. A. (1995). The duration of sprouted cerebrovascular axons following intracranial infusion of nerve growth factor. Experimental Neurology,131, (2):174-9. Abstract

Isaacson, L. G., Saffran, B. N., and Crutcher, K. A. (1992). Nerve growth factor-induced sprouting of mature, uninjured sympathetic axons. Journal of Comparative Neurology, 326, (3):327-36. Abstract

Isaacson, L. G., Saffran, B. N., and Crutcher, K. A. (1990). Intracerebral NGF infusion induces hyperinnervation of cerebral blood vessels. Neurobiology of Aging, 11(1):51-5. Abstract

Saffran, B. N., and Crutcher, K. A. (1990). NGF-induced remodeling of mature uninjured axon collaterals. Brain Research, 525(1):11-20. Abstract

Saffran, B. N., Woo, J. E., Mobley, W. C., and Crutcher, K. A. (1989). Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth. Brain Research, 492(1-2):245-54. Abstract

Crutcher, K. A. and Collins, F. (1986). Entorhinal lesions result in increased nerve growth factor-like growth-promoting activity in medium conditioned by hippocampal slices. Brain Research, 399(2):383-9. Abstract

4) Neuronal plasticity in aging

T. Cowen, I. Gavazzi, J. Weingartner and K.A. Crutcher (1996) Levels of NGF protein do not correlate with changes in innervation of the rat iris in old age, NeuroReport, 7:2216-2220. Abstract

Scott, S. A., Liang, S., Weingartner, J. A., and Crutcher, K. A. (1994). Increased NGF-like activity in young but not aged rat hippocampus after septal lesions. Neurobiology of Aging,15(3):337-46. Abstract

Crutcher, K. A. and Weingartner, J. (1991). Hippocampal NGF levels are not reduced in the aged Fischer 344 rat. Neurobiology of Aging,12(5):449-54 Abstract

Crutcher, K. A. (1990). Age-related decrease in sympathetic sprouting is primarily due to decreased target receptivity: implications for understanding brain aging. Neurobiology of Aging, 11(3):175-83. Abstract

5) NGF in Alzheimers Disease

Scott, S.A, Mufson, E.J., Weingartner, J.A., Skau, K.A. and Crutcher, K.A. (1995). Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. Journal of Neuroscience15,(9), 6213-21. Abstract

Scott, S. A., and Crutcher, K. A. (1994). Nerve growth factor and Alzheimer's disease. [Review] Reviews in the Neurosciences,5, (3):179-211. Abstract

Crutcher, K. A., Scott, S. A., Liang, S., Everson, W. V., and Weingartner J. (1993). Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. Journal of Neuroscience,13, (6):2540-50. Abstract

Crutcher, K. A., Anderson, B. H., Barger, S. W., Ohm, T. G., and Snow, A. D. (1993). Cellular and molecular pathology in Alzheimer's disease. [Review] Hippocampus,3 Spec No:271-87.

6) Plaques and ApoE in Alzheimers Disease

D.Zhang, J.-A.M. McQuade, K.P. Shockley, L. Levin, M.A. Marques and K.A. Crutcher, Proteolysis of apolipoprotein E and Alzheimer's disease pathology, Alzheimer's Reports, 4: 67-79 (2001).

M. Tolar, J.N. Keller, S. Chan, M.P. Mattson, M.A. Marques and K.A. Crutcher, Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate apoE neurotoxicity, J. Neurosci., 19:7100-7110 (1999). Abstract

M. Tolar, S.A. Scott and K.A. Crutcher, Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections, Brain Research, 787:49-58 (1998). Abstract

S. Joshi and K.A. Crutcher, Rat microglia exhibit increased density on Alzheimer’s plaques in vitro, Exp. Neurol., 149:42-50 (1998). Abstract

K.A. Crutcher, M. Tolar, J.A.K. Harmony and M.A. Marques, A new hypothesis for the role of apolipoprotein E in Alzheimer’s disease pathology, Alzheimer’s Disease: Biology, Diagnosis and Therapeutics, Eds. K. Iqbal, B. Winblad, T. Nishimura, M. Takeda and H.M. Wisniewski, John Wiley & Sons, 1997, pp. 543-552.Abstract

M.A. Marques, M. Tolar and K.A. Crutcher, Apolipoprotein E exhibits isoform-specific neurotoxicity, Alzheimer’s Research, 3:1-6 (1997).Abstract

M. Tolar, M.A. Marques, J.A.K. Harmony and K.A. Crutcher, Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated, J. Neurosci., 17:5678-5686 (1997).Abstract

M.A.Marques, M. Tolar, J.A.K. Harmony and K.A. Crutcher, A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity, NeuroReport, 7:2529-2532 (1996).Abstract

Crutcher, K. A., Clay, M. A., Scott, S. A., Tian, X., Tolar, M., Harmony, J. A. (1994). Neurite degeneration elicited by apolipoprotein E peptides. Experimental Neurology,130, (1):120-6. Abstract

Carpenter, M. K., Crutcher, K. A., and Kater, S. B. (1993). An analysis of the effects of Alzheimer's plaques on living neurons. Neurobiology of Aging,14, (3):207-15. Abstract

Crutcher, K. A., Neaderhauser, J., Schmidt, P., and Weingartner, J. (1991). Neurite outgrowth on postmortem human brain cryostat sections: studies of non-Alzheimer's and Alzheimer's tissue. Experimental Neurology, 114(2):228-36. Abstract

Other Publications

M.M. Brauer, K.P. Shockley, R. Chavez, A. Richeri, T. Cowen and K.A. Crutcher, The role of NGF in pregnancy-induced degeneration and regeneration of sympathetic nerves in the guinea pig uterus, J. Auton. Nerv. Syst., 79:19-27 (2000). Abstract

Liang, S., and Crutcher, K. A. (1993). Movement of embryonic chick sympathetic neurons on laminin in vitro is preceded by neurite extension. Journal of Neuroscience Research, 36, (6):607-20. Abstract

Crutcher, K. A. (1993). Tissue sections as culture substrates: overview and critique. [Review] Hippocampus, 3 Spec No:157-63.

Liang, S., and Crutcher, K. A. (1992). Neuronal migration on laminin in vitro. Brain Research. Developmental Brain Research, 66, (1):127-32. Abstract

Crutcher, K. A. (1991). How to succeed in science. Perspectives in Biology & Medicine,34(2):213-8. Abstract

Crutcher, K. A. (1990). Research on human embryos [letter] [see comments]. Nature, 343(6253):10.

Kesner, R. P., Crutcher, K. A., Omana, H. (1990). Memory deficits following nucleus basalis magnocellularis lesions may be mediated through limbic, but not neocortical, targets. Neuroscience, 38(1):93-102. Abstract

Kesner, R. P., Adelstein, T. B., and Crutcher, K. A. (1989). Equivalent spatial location memory deficits in rats with medial septum or hippocampal formation lesions and patients with dementia of the Alzheimer's type. Brain & Cognition, 9(2):289-300. Abstract

Crutcher, K. A. (1988). Fetal research ban [letter]. Science, 242(4883):1227.

Crutcher, K. A., Danscher, G., Geneser, F. A. (1988). Hippocampus and dentate area of the European hedgehog. Comparative histochemical study. Brain, Behavior & Evolution, 32(5):269-76. Abstract

Saffran, B. N., and Crutcher, K. A. (1987). Putative gliotoxin, alpha-aminoadipic acid, fails to kill hippocampal astrocytes in vivo. Neuroscience Letters, 81(1-2):215-20. Abstract

Kesner, R. P., DiMattia, B. V., and Crutcher, K. A. (1987). Evidence for neocortical involvement in reference memory. Behavioral & Neural Biology, 47(1):40-53. Abstract

Kesner, R. P., Adelstein, T., and Crutcher, K. A. (1987). Rats with nucleus basalis magnocellularis lesions mimic mnemonic symptomatology observed in patients with dementia of the Alzheimer's type. Behavioral Neuroscience, 101(4):451-6. Abstract

Cook, T. M., and Crutcher, K. A. (1986). Intrahippocampal injection of kainic acid produces significant pyramidal cell loss in neonatal rats. Neuroscience,18(1):79-92. Abstract

Kesner, R. P., Crutcher, K. A., Measom, M. O. (1986). Medial septal and nucleus basalis magnocellularis lesions produce order memory deficits in rats which mimic symptomatology of Alzheimer's disease. Neurobiology of Aging, 7(4):287-95. Abstract